David Dobbs’s Somatic Marker

My catch-all first filter for web-worthy offerings and gleanings 

Ezra Klein - Democrats win the Super Bowl?

According to a poll (pdf) conducted in the days before the Super Bowl, "Democrats strongly prefer the Saints, by a 36-21 margin, but Republicans are narrowly going for the Colts, 26-25. Independents lean toward the Saints as well, 33-20." Hopefully, Democrats take some lessons from their favored team, too.

Early in the game, the Saints failed to score when they had the ball on their opponent's three-yard line. Big setback, and eerily reminiscent of the metaphors many are using for health care. But then the Saints decided against walking off the field and throwing the game to the Colts. Instead, they ran their plays again and came back to win.

NB, healthcare advocates

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Shackleton's whiskey; Powell's coffee

Five crates of Scotch whisky and two of brandy have been recovered by a team restoring an Antarctic hut used more than 100 years ago by famed polar explorer Ernest Shackleton.

Five cases of Scotch and two of brandy, and all of it heavy. You can see the importance Shackleton put on a good nightcap

This puts me in mind of John Wesley Powell's Grand Canyon expedition, as described in his classic account of same. Powell had nearly as trying an adventure as Shackleton did — an 8, I would say, to Shackleton's 10 — and when he and his party finally emerged from the canyon into the world of relative safety and food, he took account of their remaining food supplies. The list, published in the book, provided pretty thin gruel. As I remember, there was a bit of flour, perhaps some corn meal and salt — hardly enough to make anything. They had clearly exhausted virtually all food supplies, save what they could catch, gather, or shoot, some time before.

There was only one thing the party (of a dozen or so, if I remember) still had in good supply. They still had 80 pounds of coffee.

I love that. I too would hate to run out of coffee, especially in a stressful envrironment. So when I think of that 80 pounds, I like to imagine the conversation as Powell and his team assembled and packed their provisions before setting out and leaving all stores behind:

"Think that's enough coffee?"

"Should be. That's a lot of coffee."

"But ..."

"What?"

"What if we run out? We can't get more."

A silence.

"You're right. Buy another two hundred pounds."

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Filed under  //   coffee   Ernest Shackleton   explorers   food   John Wesley Powell   whisky  

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via tweetie

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Neil Young- Comes A Time Farm Aid '86

I love this man.

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The Rise Of Marketing-Based Medicine (via Pharmalot)

money13You’ve heard of evidence-based medicine. Well, a new paper summarizes a panoply of practices employed over the past two decades or so - ghostwriting, suppressing or spinning data, disease mongering and managing side effect perceptions among docs - that the authors call marketing-based medicine. And they rely on internal documents from litigation - such as the much-publicized lawsuits over antipsychotics and antidepressants - to illustrate their point.

A stunning must-read from Ed Silverman on a must-read paper. The comments following Ed's post are also rich.

I imagine there will be blowback and some vigorous challenges to the facts and stats in the paper. But the industry emails quoted are themselves devastating, and suggest how successfully the marketing forces within the industry won out over those who wanted to make drugs that clearly worked, rather than aggressively sell drugs that either didn't work that well or worked for some but carried nasty side-effects that were downplayed.

Pharma, biotech, and medicine itself will be years digging out of the credibility hole this sort of thing put them in.

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Filed under  //   biotech   evidenc-based medicine   pharma   Pharmalot  

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Chess computing as a metaphor for Pharma. Who knew

The Chess Master and the Computer - The New York Review of Books
http://www.nybooks.com/articles/23592

Like so much else in our technology-rich and innovation-poor modern world, chess computing has fallen prey to incrementalism and the demands of the market. Brute-force programs play the best chess, so why bother with anything else? Why waste time and money experimenting with new and innovative ideas when we already know what works? Such thinking should horrify anyone worthy of the name of scientist, but it seems, tragically, to be the norm. Our best minds have gone into financial engineering instead of real engineering, with catastrophic results for both sectors.

(via Instapaper)

Only that would be "when we already know what sells."

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Democrats Now See ‘No Rush’ on Health Care Bill

We’re not on health care now,” Mr. Reid said. “We’ve talked a lot about it in the past.

With friends like this ...

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Why do antidepressants work only for the deeply depressed? A neuroskeptical look

http://neuroskeptic.blogspot.com/2010/01/severe-warning-for-psychiatry.html?utm_source=feedburner&utm_medium=twitter&utm_campaign=Feed%3A+ResearchBloggingAllEnglish+%28Research+Blogging+-+English+-+All+Topics%29

Which brings us back to the imaginary scenario at the start of this post. My personal interpretation of results like those of Fournier et al is this: antidepressants treat classical clinical depression, of the kind that psychiatrists in 1960 would have recognized. This is the kind of depression that they were originally used for, after all, because the first antidepressants arrived in 1953, and modern antidepressants like Prozac target the same neurotransmitter systems.

Yet in recent years "clinical depression" has become a much broader term. Many peopleattribute this to marketing on the part of pharmaceutical companies. Whatever the cause, it's almost certain that many people are now being prescribed antidepressants for emotional and personal issues which wouldn't have been considered medical illnesses until quite recently. Antidepressants also have a long history of use for other conditions, like OCD, but this is a separate issue.

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Rice, alcohol, and really fast evolution in humans

In my "Atlantic article on the genetic roots of stable-versus-reactive temperaments, I noted that the key gene variants linked to these traits appeared to have developed over only the last 50,000-100,000 years — a short time in evolutionary time. That same idea is developed in Cochran and Harpending's "The 10,000-year Explosion." Here Razib at Gene Expression looks at polymorphisms that have developed over the last 10,000 years in response to agriculture.

Changes in human diet driven by cultural evolution seem to be at the root of many relatively recently emerged patterns of genetic variation. In particular, lactase persistence and varied production of amylase are two well known cases. Both of these new evolutionary genetic developments are responses to the shift toward carbohydrates over the last 10,000 years as mainstays of caloric intake.

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Ezra Klein - America spends way, way, way more on health care

We don't have a government-run system. But our system is so expensive that our government's partial role is pricier than the whole of government-run systems.

Absorb that: Our supposedly efficient supposedly free-market healthcare system costs us more in government spending alone than other countries spend on government-run systems.

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